Gravesano, January 2022

Custom in vitro nutrition for cancer cell research

We are glad to announce the launch of synthetic custom media that allow the tuning of function and metabolism of human cancer cells. Cantor et al. and Vande Voorde et al. have independently demonstrated the usefulness of newly designed physiological media for cancer research. Particularly, such nutrient-enriched basal media include several metabolites not present in classic culture media such as RPMI 1640 and Dulbecco’s modified Eagle’s medium (DMEM). As well, the concentration of amino acids and their derivatives, non-proteinogenic amino acids, inorganic salts, trace elements, vitamins and other components is reduced and/or adapted to their respective physiological levels in human plasma.

As preparing cell culture media can be expensive and time-consuming, offering the possibility to source custom media within a few days meets with the appreciation of research scientists involved in cancer cell biology and pre-clinical development. Today we are happy to introduce our new custom-made nutrient mixtures based on the medium originally published by Vande Voorde et al. Our custom media are primarily designed to facilitate the study about the nutritional demands of the cells. As a result, we prepared a series of basal nutrient mixtures devoid of selected components such as glucose, TCA-cycle intermediates such as pyruvate, vitamins, phenol red and more. Please refer to (link) to see the list of available synthetic custom media.

Cantor, J.R., Abu-Remaileh, M., Kanarek, N., Freinkman, E., Gao, X., Louissaint, A.Jr., Lewis, C.A. and Sabatini, D.M. (2017). Cell 169, 258-272.
Vande Voorde, J., Ackermann, T., Pfetzer, N., Sumpton, D., Mackay, G., Kalna, G., Nixon, C., Blyth, K., Gottlieb, E. and Tardito, S. (2019). Sci. Adv. 5: eaau7314

To see the publication by Vande Voorde et al. in Science Advances, 2 Jan 2019, please click on the link below:

  • Improving the metabolic fidelity of cancer models with a physiological cell culture medium

    For more details about our custom-made culture media, please click on the link below:

  • CustomMade

    To see the list of custom-made physiological media, please click on the link below:

  • InVitroNutrition

    If you want to place an order please directly contact our sales department: